Regenerative medicine research
Interested in learning more about stem cell therapy, platelet-rich plasma therapy, and other regenerative medicine treatments? Here is a curated collection of articles exploring the latest research.
- Mechanisms of analgesic effect of mesenchymal stem cells in osteoarthritis pain: This article talks about osteoarthritis, a widespread joint condition causing pain and reduced mobility. Current treatments aim to manage symptoms, but they have drawbacks. Mesenchymal stem cells (MSCs) show promise in alleviating symptoms, due to their ability to mediate cell-to-cell communication and their anti-inflammatory properties. The specific pain-relieving action of MSCs in osteoarthritis involves both peripheral and central components, helping inhibit inflammation, modulate immune responses, and interact with sensory neurons.
- Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair: This article discusses the role of synovial macrophages in osteoarthritis. Synovial macrophages are a type of cell that both causes inflammation and contributes to its resolution. Current therapies for osteoarthritis that focus on reducing inflammation may hinder the resolution of the inflammation by affecting synovial macrophages. Stem cell therapy can help with joint homeostasis as it can modulate the inflammatory response, which potentially leads to the activation or recruitment of synovial macrophages as part of the joint’s healing process.
- Mesenchymal stem cells for enhancing biological healing after meniscal injuries: This article talks about how injuries to the meniscus (in the knee) are challenged by a limited ability to heal naturally, and how MSCs show promise in helping heal them.
- How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degeneration: This article is about how intervertebral disc degeneration, a major cause of chronic low back pain, often results from an imbalance between cellular breakdown and regeneration within the disc. The limited vascular supply of the disc makes the degeneration worse. Stem cell therapy with MSCs can restore disc health by promoting regeneration of cells and increasing production of extracellular matrix.
- Regulating the fate of stem cells for regenerating the intervertebral disc degeneration: Lower back pain is often caused by intervertebral disc (IVD) degeneration. Factors like aging, inflammation, and genetics contribute to this process, and the harsh disc environment exacerbates any problem. Current treatments focus on pain management and surgery, but they have limitations in restoring disc function. Regenerative medicine offers promising alternatives, aiming to promote disc regeneration and restore mechanical function while addressing the root causes of IVD degeneration.
- Mesenchymal stem cell-derived exosomes: A novel and potential remedy for cutaneous wound healing and regeneration: Traditional treatments like medications and bandages often fall short in treating a skin wound or injury, because they don’t address all the complexities involved in healing. MSCs have shown promise in promoting healing, but using them directly comes with challenges. A possible alternative: using tiny structures called exosomes, which are derived from MSCs. Exosomes act like messengers, delivering signals to encourage healing; they can reduce inflammation, stimulate blood vessel growth, and promote the growth of skin cells.
- Effects of immune cells on mesenchymal stem cells during fracture healing: When you break a bone, your body’s immune system kicks into action to help it heal. Certain types of immune cells, like neutrophils, monocytes, and macrophages, play important roles in this process. Neutrophils start the process by triggering inflammation to kick-start healing. Monocytes and macrophages, another type of immune cell, come in next to clean up the mess of the injury and start tissue repair. They send signals to MSCs, which help to rebuild the broken bone and surrounding tissues.
- Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology
- Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles
- Platelet-rich plasma vs bone marrow aspirate concentrate: An overview of mechanisms of action and orthobiologic synergistic effects
- Platelet-Rich Plasma: The Journey so Far!
- Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics
- Stem Cells for Aging-Related Disorders
- Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial
- Therapeutic Potential of Wharton’s Jelly Mesenchymal Stem Cells for Diabetes: Achievements and Challenges
- Differences and similarities between mesenchymal stem cell and endothelial progenitor cell immunoregulatory properties against T cells
- Why stem/progenitor cells lose their regenerative potential
- Stem cells: past, present, and future
- Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials